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htrB [2017-8-11 16:0:3]
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htrB [2017-8-11 16:0:3]

membrane-anchored protein quality control protease, serine protease, response to secretion and heat stresses
locus
BSU33000
pI
4.63
mw
48.55 kDa
protein length
458 aa Sequence Blast
gene length
1374 bp Sequence Blast
function
protein quality control
product
serine protease
essential
no
ec
3.4.21.107
synonyms
yvtA, yvtB
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.7|Proteolysis] → [category|SW 3.3.7.1|Protein quality control]
  • [category|SW 4|Lifestyles] → [category|SW 4.3|Coping with stress] → [category|SW 4.3.4|Heat shock proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

    • Gene

    Coordinates
    3,384,070 → 3,385,446

    The protein

    Protein family

  • peptidase S1B family (according to Swiss-Prot)

    • Structure

  • [PDB|3QO6] (from ''Arabidopsis thaliana'', 38% identity) [Pubmed|21532594]

    • [SW|Localization]

  • cell membrane (according to Swiss-Prot)
  • randomly distributed in foci throughout the cell surface [Pubmed|22307758]

    • Expression and Regulation

    Operons

    genes
    [gene|796216BE9CD6DADFEADC29497253C81BF496A2ED|htrB]
    description
    [Pubmed|22383849]

    regulatory mechanism

  • [protein|A40CD2C23A19860342F440284302EFFDAC09E88A|CssR]: activation, [Pubmed|12270824], in [regulon|A40CD2C23A19860342F440284302EFFDAC09E88A|CssR regulon]

    • regulation

  • expressed under conditions of secretion stress ([protein|A40CD2C23A19860342F440284302EFFDAC09E88A|CssR]) [Pubmed|12270824]

    • additional information

  • [protein|796216BE9CD6DADFEADC29497253C81BF496A2ED|HtrB] is subject to degradation by [protein|DC0FDCA3FA6742B023E6877CE9554AA1D47012BB|WprA] and other extracellular proteases [PubMed|24362423]
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    Biological materials

    Mutant

  • MGNA-B207 (yvtA::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/1206 NBRP B. subtilis, Japan]

    • References

    Reviews

  • 22688815,21326199,25212246

    • Original publications

  • 17600057,22307758,12270824,22092710,24362423,24115457,11133960,21532594